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CDC Data Show 80 Percent Increase In HIV Among Young African American Men Who Have Sex With MenYesterday, the Centers for Disease Control and Prevention finally released data it had long held internally that demonstrate an alarming increase in the number of HIV/AIDS cases among African American young men who have sex with men (YMSM). The report, CDC HIV/AIDS Update: New Surveillance Slide Set on Men Who Have Sex with Men (MSM), shows that in the 33 states that collected data, the number of HIV/AIDS cases increased among adult and adolescent men who have sex with men (MSM) in all age groups from 2001 through 2005. The largest proportional increase , however, occurred among MSM ages 13-24, with African American/black YMSM in this age category suffering the largest increase -- up from 928 cases in 2001 to 1,618 cases in 2005. "This dramatic increase in HIV rates is yet another in a series of clarion calls to Congress and the Department of Health and Human Services that young people need culturally relevant and realistic sex education to protect their health and save their lives," urged Debra Hauser, Executive Vice President at Advocates for Youth. "The fact that this report comes on the heels of new data showing that 1 in 4 teen girls has had a sexually transmitted disease is further proof that the Administration's failed abstinence-only policy is putting young people in danger." Earlier this year, the CDC also released data demonstrating that teen birth rates had increased for the first time in more than a decade. "We will never be able to adequately address the sexual health needs of young people when our government insists upon funding abstinence-only-until-marriage programs that censor vital information about contraception and condoms and demonize homosexuality. All young people have the right to honest sexual health information," concluded Ms. Hauser. Advocates for Youth is a national, nonprofit organization that creates programs and supports policies that help young people make safe, responsible decisions about their sexual and reproductive health. Advocates for Youth http://www.advocatesforyouth.org
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www.weightlossdietwatch.com>Weight Loss Diet Watch blog helps you learn everything you need to know about weight loss and various healthy diet plans. Know more about controlling your weight, and maintaining a healthy life; Visit www.weightlossdietwatch.com/
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"The prospect of personalized medicine has received much hype, but until recently, there has been little hard evidence to support the promise," says Sekar Kathiresan, MD, MGH Director of Preventive Cardiology, the paper's lead author. "We feel that our data provides two insights. First, we provide a foundation for the possibility that a panel of gene variants will eventually be useful in preventive cardiac care. Second, we show that the combination of multiple variants related to cholesterol importantly contribute to the genetic risk for heart attack." It is estimated that about half the variation in high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol levels is inherited, rather than being caused by lifestyle factors such as diet and exercise. While studies have associated several gene variants with cholesterol levels, exactly how those variants impact the risk of cardiovascular disease is unclear. The current study was designed to explore the influence of those variants on the risk of cardiovascular events -- heart attack, stroke or sudden cardiac death -- and whether measuring such variants could help predict risk better than simply measuring HDL and LDL levels. Since the effects of individual gene variants appears slight, the research team looked at a combination of 9 single-nucleotide polymorphisms (SNPs) previously associated with cholesterol levels. They analyzed data from 5,414 Swedish adults who participated in a major prospective epidemiological study and correlated data -- including standard measurements of HDL and LDL cholesterol and the presence of the 9 gene variants -- with information on the participants' subsequent medical histories available from a registry of information collected on all Swedish citizens. After the initial genotyping of participants not receiving lipid-lowering therapy, participants were assigned a genotype score ranging from 0 to 18, based on how many copies of the unfavorable SNPs they carried. Of the participants who had no cardiovascular events before enrolling in the study, 238 suffered a heart attack, stroke or cardiac death during the subsequent 10.6 years. Higher genotype scores did reflect higher LDL ("bad") cholesterol and lower HDL ("good") cholesterol levels. Importantly, those with genotype scores of 11 or higher had a 63 percent greater risk of a cardiovascular event than did those with scores of 9 or lower. Although testing for the panel of 9 SNPs was not better than standard risk factors for predicting cardiac events in the overall population, among participants classified at intermediate risk by standard measures, adding the 9-SNP panel significantly improved the ability to distinguish truly elevated or reduced risk levels. "A current clinical dilemma is how early to start patients on cholesterol-lowering medications like statins that can reduce the risk of heart attack. Our data suggest that those individuals classified as higher risk based on a genetic test may deserve more intense pharmacological and lifestyle treatments," says Kathiresan. "But before we can move from our pilot data to information that can impact the care of patients with or at risk for cardiovascular disease, we need to discover all the risk-related variants -- and there will probably be 50 to 100 -- and then conduct clinical studies confirming that this information can reliably guide patient care." Earlier this year Kathiresan, an instructor in Medicine at Harvard Medical School, and colleagues from the Broad Institute of Massachusetts Institute of Technology and Harvard University began this gene-discovery process and identified six new cholesterol-associated gene variants in a separate study published in Nature Genetics. Support for the NEJM study includes grants from the Doris Duke Charitable Foundation, the Fannie Rippel Foundation, the Donovan Family Foundation and the National Institutes of Health. Study co-authors are David Altshuler, MD, PhD, and Christopher Newton-Cheh, MD, MPH, MGH; Olle Melander, MD, PhD, Dragi Anevski, PhD, Charlotta Roos, MSc, Goran Berglund, MD, PhD, Bo Hedblad, MD, PhD, Leif Groop, MD, PhD, and Marju Orho-Melander, PhD, Lund University, Sweden; Candace Guiducci and Noel Burtt, Broad Institute; and Joel Hirschhorn, MD, PhD, Children's Hospital Boston. Adapted from materials provided by Massachusetts General Hospital, via EurekAlert!, a service of AAAS.
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